| |
|
|
| |
 | Volume 14, Number 3 (Fall 2010 2010) |  | |
| |
 | Age-dependent dynamic electrophysiological field potential behavior of atrioventricular node during experimental AF in rabbit |  |
| | Author(s): vahid khori, saed saleki, aref salehi, alimohammad alizadeh, mona pourabouk, fakhri badaghabadi, shima changizi and mohsen nayebpour | | | Study Type: Original Research | Subject: Cardivascular system | | | Article abstract: | | Introduction: Electrophysiological studies have demonstrated a relationship between aging and atrioventricular
(AV) nodal conduction and refractoriness. The aim of the present study was to determine the effects of nodal aging on
dynamic AV nodal field potential recording during atrial fibrillation (AF) in rabbit.
Methods: Two groups of male New Zealand rabbits (neonatal 2-week-olds and adult 12-week-olds, n=14 each
group) were used in this study. Field potential recordings were executed by silver electrodes with a diameter of 100 M.
Pre-defined stimulation protocols of AF, zone of concealment (ZOC) and concealed conduction for determination of the
electrophysiological properties of the AV-node were separately applied in each group.
Results: Results of the study showed that mean ventricular rate (HH) during atrial fibrillation was smaller in the
neonatal compared to the adult group (229.1 ± 8.3 versus 198.6 ± 13.1 msec, respectively). Also ventricular distribution
conduction pattern showed two peaks in the adult and one peak in the neonatal group. Analyzing the zone of
concealment in different rates and after concealed beat indicated that the zone of concealment in neonates were
significantly smaller compared with adult rabbits and increasing zone of concealment, which is accompanied with
increasing ventricular rate is abrogated in the neonatal group (5 ± 3.3, 12.2 ± 6.3 msec).
Conclusion: The results of this study showed that the electrophysiological protective dynamic behavior of the AV
node during atrial fibrillation is smaller in neonates compared to adults. Narrower zone of concealment, abrogation rate
dependent trend of the zone of concealment and shorter nodal refractoriness can account for the specific nodal
electrophysiological properties of neonatal rabbits.
| | | Keywords: Age, AV node, Atrial Fibrillation (AF), Zone of Concealment (ZOC), | |
| Full text [PDF 945 kb] | | | |
| | How to cite this article | Download citation data for: BibTeX | EndNote | Medlars | ProCite | Reference Manager | RefWorks |
Send citation data to: CiteULike | RefWorks | | khori vahid, saleki saed, salehi aref, alizadeh alimohammad, pourabouk mona, badaghabadi fakhri et al. et al. Age-dependent dynamic electrophysiological field potential behavior of atrioventricular node during experimental AF in rabbit Physiology and Pharmacology, 2010; 14 (3) :199-210 URL http://www.phypha.ir/ppj/browse.php?a_code=A-10-245-6&slc_lang=en&sid=1 | | |
| | |
| |
| |
| Address: Neuroscience Research Center, P.O.Box: 19615-1178, I.R.Iran, Fax:+98-21-22431624, Tel:+98-21-22429765-7. | |
| |
| |
| |
